Alcoholic ketoacidosis: MedlinePlus Medical Encyclopedia

There are inevitable limitations of a post-mortem study performed under current patterns of practice in the UK. Nevertheless, we believe that our study has demonstrated that fatal arrhythmia in association with fatty liver and chronic excess alcohol consumption is a significant public health issue for the UK. It may account for around 1,000 deaths per annum in England and Wales with many of these deaths currently misattributed to other causes or simply unexplained. With the current trend for escalating alcohol abuse, in particular binge drinking, in the UK, much of the previous literature on this topic (which is decades old and not from the UK) is now not relevant.

Alcoholic ketoacidosis: definition and clinical features

• All relevant ethical issues were identified and discussed with the local Ethical Committee.
• Many patients with alcoholic ketoacidosis have been found to have extremely elevated concentrations of plasma free fatty acids, with mean levels much higher than those observed in patients with diabetic ketoacidosis (Levy et al., 1973; Cooperman et al., 1974; McGuire et al., 2006).
• Although previous series of the scenario of sudden death in association with fatty liver in alcoholics have been published, these are mainly from outside of the UK and are published in languages other than English [9,15,16].

It will also briefly review what a high lactate level means regarding potential medical outcomes. The greatest threats to patients with alcoholic ketoacidosis are marked contraction in extracellular fluid volume (resulting in shock), hypokalaemia, hypoglycaemia, and acidosis. We present a 64-year-old female who presented with generalized abdominal pain, nausea, vomiting and shortness of breath. Arterial blood gas analysis showed significant acidaemia with a pH of 7.10, bicarbonate of 2.9 mmol/l and lactate of 11.7 mmol/l.

• Lactic acidosis occurs when ethanol metabolism results in a high hepatic NADH/NAD ratio, diverting pyruvate metabolism towards lactate and inhibiting gluconeogenesis.
• The paucity of publications on this topic may be in part attributable to the fact that biochemical analyses are not integrated in routine autopsy investigations in most medico-legal centers or are limited to the determination of specific compounds (acetone) exclusively in blood.
• Arterial blood gas and biochemistry studies reveal a raised anion gap metabolic acidosis without evidence of lactic or diabetic ketoacidosis.
• Alcohol killed a record number of people in 2022 as heavier drinking in the Covid pandemic took its toll in the UK, official figures have revealed.
• The greatest threats to patients with alcoholic ketoacidosis are marked contraction in extracellular fluid volume (resulting in shock), hypokalaemia, hypoglycaemia, and acidosis.
• Free fatty acids were quantified in postmortem serum from femoral blood by the enzymatic colorimetric method ‘NEFA-HR(2)’ (Wako Diagnostics, USA) adapted on a Cobas MIRA Plus (Roche Diagnostics, Switzerland).

How Can Alcoholic Ketoacidosis Be Prevented?

This literature review discusses the history, characterisation, pathophysiology, diagnosis, and management of AKA. When your body burns fat for energy, byproducts known as ketone bodies are produced. If your body is not producing insulin, ketone bodies will begin to build up in your bloodstream. This buildup of ketones can produce a life-threatening condition known as ketoacidosis.

What’s the Outlook for Lactic Acidosis?

Laboratory analysis plays a major role in the evaluation of a patient with suspected alcoholic ketoacidosis. Refrigerated or frozen samples thawed overnight at 4°C were deproteinized with perchloric acid and supernatant was used for analysis. If your blood glucose level is elevated, your doctor may also perform a hemoglobin A1C (HgA1C) test. This test will provide information about your sugar levels to help determine whether you have diabetes. The condition is an acute form of metabolic acidosis, a condition in which there is too much acid in body fluids. That 33% jump in deaths from alcohol means 10,048 people died from alcohol-specific causes – the highest level since records began in 2001 and a sharp increase on the pre-pandemic trend that had been steady since 2012.

BOX 3 MANAGEMENT OF AKA

If you have symptoms of alcoholic ketoacidosis, your doctor will perform a physical examination. If your doctor suspects that you’ve developed this condition, they may order additional tests to rule out other possible conditions. It was first described in 1926 that there is an association between fatty changes within the liver due to alcohol and sudden (presumed) arrhythmic death [4,5]. These deaths typically occur in white alcoholic ketoacidosis smell males who are greater than 50 years old with a negative or low blood alcohol and the liver usually depicts fatty change rather than cirrhosis [6]. The mechanism of death is not fully understood, but thought to be due to a variety of metabolic disturbances triggered by massive ethanol intake and starvation [7] resulting in cardiac arrhythmia. Post mortems on these cases are essentially negative, showing only liver steatosis.

Who Is at Risk for Lactic Acidosis From Metformin?

The toxicokinetics that are pertinent to the diagnosis of AKA include the rate of alcohol oxidation in the body. Ethyl alcohol oxidizes at a rate of 20 to 25 mg/dL per hour in most individuals. The accompanying lack of alcohol in the patient’s body and the fact that for some time, the only source of calories that a patient has is ethanol both contribute to the clinical syndrome that we see. IL-10 was measured in postmortem serum from femoral blood by the ELISA technique using a commercially available kit. IL-6 was measured in postmortem serum from femoral blood by the enzyme-linked immunosorbent assay (ELISA) technique using a commercially available kit (R&D System, Inc., Minneapolis, MN, USA). LBP was determined in postmortem serum from femoral blood by chemiluminescent immunometric assay Immulite®2000 (Siemens Medical, Germany).

All chronic alcohol misusers attending the ED should receive intravenous B vitamins as recommended by The Royal College of Physicians.23 Strenuous efforts must be made to exclude concomitant pathology. Wrenn et al found altered mental status in 15% of patients, attributable in all but one case to hypoglycaemia, severe alcohol intoxication, or infection. Fever was seen in only two patients, both with other likely underlying causes. Lactic acid levels are often elevated because of hypoperfusion and the altered balance of reduction and oxidation reactions in the liver. Glucose was analyzed in vitreous and urine stored in preservative-free tubes on the Roche Modular P clinical chemistry system (glucose hexokinase method).

Symptoms of Alcoholic Ketoacidosis

It is essential to administer thiamine before any glucose administration to avoid Wernicke’s encephalopathy preci[itation. If severe hypokalemia is present dextrose containing fluids can be held until potassium levels are normalized. Other electrolyte abnormalities concomitantly present with alcohol abuse and poor oral intake include hypomagnesemia and hypophosphatemia. Magnesium and phosphate levels should be measured and repleted if the serum levels are found low. Lastly, all individuals studied were hyperuricemic, a condition that has also been found in patients with diabetic and starvation-induced ketosis (Fulop and Hoberman, 1975).

• Although well described in international emergency medicine literature, UK emergency physicians rarely make the diagnosis of AKA.
• Hypovolemic shock symptoms and signs are similar to septic shock, although fever and warm skin are absent.
• Signs of shock including tachycardia and hypotension can be complicated by overlap of alcohol withdrawal [2].
• In terms of establishing the presence of chronic alcohol misuse at post mortem, blood alcohol is generally not a useful marker as it falls to normal relatively rapidly after cessation of drinking and therefore only indicates the level of acute alcohol consumption.

Heavier drinking during Covid led to 2,500 more deaths from alcohol in 2022 – ONS

Exceptions are the reports pertaining to acetone and beta-hydroxybutyrate determination and, more recently, CRP measurement. This lack of literature may seem surprising, especially considering that alcoholic ketoacidosis is commonly found in ethanol abusers in emergency departments worldwide. Furthermore, deaths related to chronic ethanol consumption account for a significant part of the forensic work (Denmark, 1993; Höjer, 1996). The key differential diagnosis to consider, and exclude, in these patients is DKA. Although DKA can also present with a severe metabolic acidosis, with a raised anion gap and the presence of ketones, the history and examination are quite distinct from that of someone presenting with AKA (Table 1). The main differential diagnoses for ketosis in our patient included AKA, starvation/fasting ketosis and DKA.

Table 4 shows the numbers of deaths in each of the Davies’ criteria groups 1–5 in the alcohol excess group versus the non alcohol excess group. In the alcohol excess group, there were relatively fewer deaths compared to the non alcohol excess cases in groups 1, 2 and 3, i.e., the deaths where we can be more certain about the cause of death. Interestingly, there is an increased proportion of Davies criteria 5 deaths (4.3% of cardiac deaths versus 1.3% in the non-alcohol excess group).